Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.68 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.56 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986935 | 0.93 | PPARG (0.68) | PPARGAGTR1AGTR2MEN1BLM | |
| SCHEMBL6170958 | 0.85 | AGTR1 (0.62) | PPARGAGTR1AGTR2MEN1BLM | |
| SCHEMBL7986953 | 0.85 | PPARG (0.69) | PPARGAGTR1AGTR2MEN1BLM | |
| SCHEMBL8000081 | 0.82 | PPARG (0.77) | PPARGAGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL7997803 | 0.81 | PPARG (0.75) | PPARGAGTR1AGTR2 | |
| SCHEMBL6169805 | 0.81 | PPARG (0.56) | PPARGAGTR1AGTR2 | |
| SCHEMBL6171210 | 0.80 | AGTR1 (0.62) | PPARGAGTR1AGTR2 | |
| SCHEMBL8000001 | 0.79 | PPARG (0.69) | PPARGAGTR1AGTR2MEN1BLM | |
| SCHEMBL9087920 | 0.78 | AGTR1 (0.76) | PPARGAGTR1AGTR2 | |
| SCHEMBL6168507 | 0.77 | PPARG (0.54) | PPARGAGTR1AGTR2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288100-B1 | SUCH AS PHENYL-(2-PROPYL-1H-BENZIMIDAZOL-5-YL)-METHANONE USEFUL AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| EP-0830343-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039390-A1 | BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |