Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000470 | 0.89 | DRD4 (0.66) | KDRDRD4ALDH1A1MAPTKDM4E | |
| SCHEMBL8011728 | 0.88 | DRD4 (0.59) | KDRDRD4MAPTPDGFRBHTR1A | |
| SCHEMBL8009072 | 0.77 | DRD4 (0.73) | DRD4SIGMAR1HTR1AHTR2CDRD2 | |
| SCHEMBL1389022 | 0.76 | KDR (0.52) | KDRDRD4SIGMAR1HTR1AHTR2C | |
| SCHEMBL8010100 | 0.76 | KDR (0.49) | KDRDRD4ALDH1A1MAPTKDM4E | |
| SCHEMBL8009156 | 0.75 | DRD4 (0.67) | DRD4SIGMAR1 | |
| SCHEMBL8010052 | 0.75 | DRD4 (0.64) | DRD4SIGMAR1HTR1AHTR2CDRD2 | |
| SCHEMBL8011495 | 0.75 | HRH4 (0.65) | KDRALDH1A1MAPTKDM4ELMNA | |
| Oxalic Acid SCHEMBL8011723 | 0.73 | DRD4 (0.67) | DRD4SIGMAR1HTR1AHTR2CDRD2 | |
| SCHEMBL1388359 | 0.71 | KDR (0.47) | KDRDRD4SIGMAR1HTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080745-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LIMITED (GB) | 2000-06-27 | — | — | US | claimed |
| EP-0724572-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1998-12-16 | — | — | EP | claimed |
| EP-0724572-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-08-07 | — | — | EP | claimed |
| WO-1995007893-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | claimed |
| US-6080745-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0724572-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1998-12-16 | — | — | EP | disclosed |
| EP-0724572-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995007893-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |