Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011492 | 0.79 | HRH1 (0.51) | MAPTHTR1AHTR2CDRD4SIGMAR1 | |
| SCHEMBL8012046 | 0.78 | MC4R (0.49) | MC4RALDH1A1MAPT | |
| SCHEMBL8000401 | 0.77 | DRD4 (0.57) | ALDH1A1LMNAHTR1AHTR2CTSHR | |
| SCHEMBL8000065 | 0.76 | KDR (0.60) | KDRMC4RALDH1A1MAPTKDM4E | |
| SCHEMBL8011495 | 0.75 | HRH4 (0.65) | KDRALDH1A1MAPTKDM4EHPGD | |
| Oxalic Acid SCHEMBL8010108 | 0.75 | HRH1 (0.47) | MAPTHTR1AHTR2CDRD4SIGMAR1 | |
| SCHEMBL20445526 | 0.73 | SMO (0.56) | MC4RALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL20438318 | 0.70 | MEN1 (0.51) | MC4RALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL18282528 | 0.69 | SMO (0.49) | MC4RALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL2961731 | 0.68 | HTR3E (0.54) | MC4RALDH1A1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080745-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LIMITED (GB) | 2000-06-27 | — | — | US | claimed |
| EP-0724572-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1998-12-16 | — | — | EP | claimed |
| EP-0724572-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-08-07 | — | — | EP | claimed |
| WO-1995007893-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | claimed |
| US-6080745-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0724572-B1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1998-12-16 | — | — | EP | disclosed |
| EP-0724572-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995007893-A1 | FUSED TRICYCLIC HETEROAROMATIC DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | disclosed |