Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 19/20 | 0.85 |
| ▸ | MMP1 | P03956 | 10/20 | 0.85 |
| ▸ | MMP3 | P08254 | 6/20 | 0.80 |
| ▸ | MMP9 | P14780 | 3/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998644 | 0.92 | MMP2 (0.85) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7505271 | 0.92 | MMP2 (1.00) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7503635 | 0.91 | MMP2 (1.00) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7501644 | 0.90 | MMP2 (0.96) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7504624 | 0.90 | MMP2 (1.00) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7507791 | 0.89 | MMP2 (0.80) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7501269 | 0.89 | MMP2 (1.00) | MMP2MMP1MMP3MMP9ALDH1A1 | |
| SCHEMBL7509124 | 0.88 | MMP2 (1.00) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7508422 | 0.88 | MMP2 (1.00) | MMP2MMP1MMP3MMP9 | |
| SCHEMBL7504651 | 0.88 | MMP2 (1.00) | MMP2MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |