Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.55 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.55 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246377 | 1.00 | GRIK1 (0.55) | GRIK1GRIK2FFAR3HDAC3HDAC1 | |
| SCHEMBL811730 | 1.00 | GRIK1 (0.55) | GRIK1GRIK2FFAR3HDAC3HDAC1 | |
| SCHEMBL21635680 | 0.98 | GRIK1 (0.53) | GRIK1GRIK2FFAR3HDAC3HDAC1 | |
| SCHEMBL21635654 | 0.98 | GRIK1 (0.53) | GRIK1GRIK2FFAR3HDAC3HDAC1 | |
| SCHEMBL21635669 | 0.98 | GRIK1 (0.53) | GRIK1GRIK2FFAR3HDAC3HDAC1 | |
| SCHEMBL7559357 | 0.86 | GRIK1 (0.52) | GRIK1GRIK2EP300CES2CES1 | |
| SCHEMBL6687353 | 0.86 | GRIK1 (0.58) | GRIK1GRIK2FFAR3HDAC3HDAC1 | |
| SCHEMBL29001273 | 0.86 | GRIK1 (0.52) | GRIK1GRIK2FFAR3HDAC3HDAC1 | |
| SCHEMBL811600 | 0.86 | GRIK1 (0.52) | GRIK1GRIK2EP300CES2CES1 | |
| SCHEMBL3020013 | 0.86 | GRIK1 (0.47) | GRIK1GRIK2FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160151322-A1 | METALLO-B-LACTAMASE INHIBITORS | MEIJI SEIKA KAISHA (JP) | 2016-06-02 | — | — | US | disclosed |
| US-9260375-B2 | Metallo-β-lactamase inhibitors | MEIJI SEIKA KAISHA, LTD. (JP) | 2016-02-16 | — | — | US | disclosed |
| US-9115079-B2 | NDM inhibitor | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2015-08-25 | — | — | US | disclosed |
| US-20140221330-A1 | NDM INHIBITOR | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2014-08-07 | — | — | US | disclosed |
| US-20120071457-A1 | METALLO-BETA-LACTAMASE INHIBITORS | CHIKAUCHI KEN (JP) | 2012-03-22 | — | — | US | disclosed |
| EP-1227111-A1 | TRIPHENYLBORON-CONTAINING POLYMERS AND USE THEREOF | Yoshitomi Fine Chemicals, Ltd. (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-4143020-A | COPOLYMERS OF SULFONIC ACID MONOMERS | ROHM AND HAAS COMPANY (US) | 1979-03-06 | — | — | US | disclosed |
| US-4131736-A | Polymers of sulfonic acid monomers | ROHM AND HAAS COMPANY (US) | 1978-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071457-A1 | METALLO-BETA-LACTAMASE INHIBITORS | ME1, MGAM, GAA | GRIK1 2255/4885GRIK2 2664/4885FFAR3 4843/4885 |
| US-20140221330-A1 | NDM INHIBITOR | MGAM, NQO1, NQO2 | GRIK1 4072/4885GRIK2 4385/4885FFAR3 4695/4885 |
| US-20160151322-A1 | METALLO-B-LACTAMASE INHIBITORS | ME1, MGAM, MANBA | GRIK1 2469/4885GRIK2 2749/4885FFAR3 4849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.