ME1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2310924	0.58	8/20
SCHEMBL1128293	0.55	7/20
SCHEMBL1977631	0.52	6/20
SCHEMBL2312197	0.51	6/20
Hydrochloric Acid (SCHEMBL2255585)	0.47	6/20
SCHEMBL2158309	0.60	5/20
SCHEMBL2236040	0.59	5/20
SCHEMBL2357897	0.55	5/20
SCHEMBL2312297	0.49	5/20
SCHEMBL1735467	0.47	5/20
SCHEMBL1733516	0.46	5/20
SCHEMBL2312088	0.44	5/20
SCHEMBL2346745	0.42	5/20
SCHEMBL2306481	0.62	4/20
SCHEMBL1904981	0.58	4/20
SCHEMBL2288557	0.55	4/20
SCHEMBL1136936	0.49	4/20
SCHEMBL2158310	0.48	4/20
SCHEMBL110127	0.48	4/20
SCHEMBL2312607	0.47	4/20

Clinical trials — most relevant to ME1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Supplementation With Lactoferrin in Preterm Newborns	PHASE4	COMPLETED
Glutamate for Metabolic Intervention in Coronary Surgery	PHASE3	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
IST Neoadjuvant Abraxane in Newly Diagnosed Breast Cancer	PHASE2	UNKNOWN
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses	PHASE2	COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors	PHASE1	COMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)	nan	NOT_YET_RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Systemic Biomarkers of Brain Injury From Hyperammonemia	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors	nan	UNKNOWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Clinical and Laboratory Study of Methylmalonic Acidemia	nan	RECRUITING
Serum Zinc and Serum Magnesium in Chronic Liver Disease Patients	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Cardiotoxicity of Aluminum Phosphide Poisoning; Tropinin and CKmb as Early Biomarkers	nan	UNKNOWN
The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS	nan	COMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy	nan	UNKNOWN
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN)	nan	UNKNOWN
EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases	nan	COMPLETED
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Health Impacts of Sustainable Ingredient Selection in the Food and Drink Industry - ALTERNATIVE PROTEIN STUDY	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ME1 binder may also engage these)

Protein	Name	Similarity
Q29558	—	1.000	Q29558 →
P13697	—	1.000	P13697 →
P28227	—	1.000	P28227 →
P40927	—	1.000	P40927 →
P06801	—	0.999	P06801 →
Q8BMF3	—	0.995	Q8BMF3 →
Q9XGZ0	—	0.994	Q9XGZ0 →
Q9LYG3	—	0.992	Q9LYG3 →
P12628	—	0.991	P12628 →
P51615	—	0.991	P51615 →
P37223	—	0.990	P37223 →
ME3	NADP-dependent malic enzyme, mitochondrial	0.990	landscape →
P34105	—	0.990	P34105 →
P37222	—	0.990	P37222 →
Q99KE1	—	0.989	Q99KE1 →
O82191	—	0.989	O82191 →
ME2	NAD-dependent malic enzyme, mitochondrial	0.988	landscape →
A8E657	—	0.986	A8E657 →
Q9UDR5	—	0.985	Q9UDR5 →
P36444	—	0.984	P36444 →
P43279	—	0.982	P43279 →
P22178	—	0.982	P22178 →
PC	Pyruvate carboxylase, mitochondrial	0.982	landscape →
Q9V6U8	—	0.981	Q9V6U8 →
Q9CA83	—	0.981	Q9CA83 →
P52873	—	0.980	P52873 →
P27443	—	0.980	P27443 →
Q99K67	—	0.980	Q99K67 →
Q64HZ8	—	0.980	Q64HZ8 →
Q64I01	—	0.980	Q64I01 →