SCHEMBL8000930

SCHEMBL8000930

CC(C)N(CCNCc1cccnc1)C(C)C

nearest known ligand 0.59

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.59
CYP2D6 P10635 1/20 0.59
CHRM2 P08172 1/20 0.58
ALDH1A1 P00352 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
SCN8A Q9UQD0 1/20 0.49
HTT P42858 1/20 0.49
CHRNB2 P17787 1/20 0.49
CHRNA4 P43681 1/20 0.49
TP53 P04637 1/20 0.47
POLB P06746 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8001649 0.83 CYP1A2 (0.65) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL8851564 0.80 KMT2A (0.57) CHRM2ALDH1A1SCN8ATDP1
SCHEMBL19031318 0.80 CYP1A2 (0.83) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL29875178 0.80 CYP1A2 (0.83) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL3738479 0.77 CYP1A2 (0.71) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL22878304 0.77 CYP1A2 (0.71) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL18423894 0.77 CYP1A2 (0.61) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL82613 0.77 CYP1A2 (0.61) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL9570421 0.77 CHRM2 (0.69) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1
SCHEMBL11594897 0.77 CHRM2 (0.93) CYP1A2CYP2D6CHRM2ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057318-A ANTAGONISTS OF PLATELET ACTIVATING FACTOR ACETHER SANOFI (FR) 2000-05-02 US disclosed
US-5891893-A 5-AMINO-1,2,4-OXA(OR THIA)DIAZOLES; ANTAGONISTS OF PLATELET ACTIVATING FACTOR USEFUL IN TREATMENT OF ASTHMA, ALLERGIES, INFLAMMATION, CARDIOVASCULAR DISEASES, RENAL DISEASES, OR AS CONTRACEPTIVES SANOFI (FR) 1999-04-06 US disclosed
US-5891894-A 2-AMINO OXAZOLE DERIVATIVES; ANTAGONISTS OF PLATELET ACTIVATING FACTOR USEFUL IN TREATMENT OF ASTHMA, INFLAMMATION, CARDIOVASCULAR DISORDERS, RENAL DISEASES, OR AS CONTRACEPTIVES SANOFI (FR) 1999-04-06 US disclosed
US-5780468-A ANTAGONIST OF PLATELET ACTIVATING FACTOR SANOFI (FR) 1998-07-14 US disclosed
US-5470855-A Anticoagulants SANOFI (FR) 1995-11-28 US disclosed