Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27339544 | 0.88 | MAOA (0.61) | KMT2AMEN1TDP1MAOACHRM2 | |
| SCHEMBL8000930 | 0.80 | CYP1A2 (0.59) | TDP1CHRM2ALDH1A1SCN8A | |
| SCHEMBL133622 | 0.79 | MEN1 (0.64) | KMT2AMEN1TDP1MAOACHRM2 | |
| SCHEMBL5867349 | 0.78 | ALDH1A1 (0.49) | KMT2AMEN1TDP1CHRM2GAA | |
| SCHEMBL4502698 | 0.78 | MEN1 (0.70) | KMT2AMEN1TDP1MAOACHRM2 | |
| Ammonia Solution, Strong SCHEMBL16268586 | 0.77 | MEN1 (0.61) | KMT2AMEN1TDP1MAOACHRM2 | |
| Isopropyl Alcohol SCHEMBL17927504 | 0.76 | MEN1 (0.74) | KMT2AMEN1TDP1MAOACHRM2 | |
| Isopropylamine SCHEMBL2769495 | 0.76 | MEN1 (0.74) | KMT2AMEN1TDP1MAOACHRM2 | |
| SCHEMBL455309 | 0.76 | MEN1 (0.59) | KMT2AMEN1TDP1MAOACHRM2 | |
| SCHEMBL5764 | 0.75 | MEN1 (1.00) | KMT2AMEN1TDP1MAOACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053472-C | Oligonucleotides derived from the SOD family | HOFFMANN LA ROCHE (CH) | 2000-06-14 | — | — | CN | disclosed |
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| CN-1106405-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | CN | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |