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Dexbudesonide

Dexbudesonide

SCHEMBL8001479

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nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Dexbudesonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 7/20 0.67
▸ CYP3A4 P08684 8/20 0.67
▸ HIF1A Q16665 7/20 0.67
▸ PGR P06401 5/20 0.67
▸ HSD17B10 Q99714 4/20 0.67
▸ ABCB11 O95342 3/20 0.67
▸ NR3C2 P08235 2/20 0.67
▸ AR P10275 2/20 0.67
▸ LMNA P02545 2/20 0.67
▸ CYP2C9 P11712 2/20 0.67
▸ ABCC4 O15439 2/20 0.67
▸ ABCC3 O15438 1/20 0.67
▸ IL5 P05113 1/20 0.67
▸ CHRM1 P11229 1/20 0.67
▸ MMP9 P14780 1/20 0.67
▸ NFKB1 P19838 1/20 0.67
▸ THPO P40225 1/20 0.67
▸ SMN1; SMN2 Q16637 1/20 0.67
▸ BLM P54132 1/20 0.67
▸ PMP22 Q01453 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dexbudesonide SCHEMBL5655286 0.88 NR3C1 (0.88) CYP3A4HIF1ANR3C1PGRHSD17B10
Dexbudesonide SCHEMBL8159866 0.82 NR3C1 (0.78) CYP3A4HIF1ANR3C1PGRHSD17B10
Prednisolone Acetate SCHEMBL7036043 0.82 HIF1A (0.71) CYP3A4HIF1ANR3C1PGRHSD17B10
Dexbudesonide SCHEMBL4260550 0.82 CYP3A4 (0.73) CYP3A4HIF1ANR3C1PGRHSD17B10
Dexbudesonide SCHEMBL18695366 0.82 CYP3A4 (0.73) CYP3A4HIF1ANR3C1PGRHSD17B10
Dexbudesonide SCHEMBL141510 0.82 NR3C1 (0.97) CYP3A4HIF1ANR3C1PGRHSD17B10
Budesonide SCHEMBL13695912 0.82 NR3C1 (1.00) CYP3A4HIF1ANR3C1PGRHSD17B10
Budesonide SCHEMBL14452945 0.82 NR3C1 (1.00) CYP3A4HIF1ANR3C1PGRHSD17B10
Budesonide SCHEMBL8056801 0.82 NR3C1 (1.00) CYP3A4HIF1ANR3C1PGRHSD17B10
Budesonide SCHEMBL21570019 0.82 NR3C1 (1.00) CYP3A4HIF1ANR3C1PGRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831912-A4 IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS OCULEX PHARM INC (US) 2000-08-30 — — EP disclosed
EP-0831912-A1 IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS OCULEX PHARMACEUTICALS, INC. (US) 1998-04-01 — — EP disclosed
WO-1996038174-A1 IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS OCULEX PHARMACEUTICALS, INC. (US) 1996-12-05 — — WO disclosed
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