Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 4/20 | 0.45 |
| ▸ | FAP | Q12884 | 3/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 6/20 | 0.40 |
| ▸ | REN | P00797 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29569027 | 0.95 | XIAP (0.53) | XIAPDPP4FAPDPP7PREP | |
| SCHEMBL9003027 | 0.89 | XIAP (0.49) | XIAPDPP4FAPDPP7PREP | |
| SCHEMBL10749206 | 0.85 | XIAP (0.49) | XIAPDPP4FAPDPP7PREP | |
| SCHEMBL10749197 | 0.85 | XIAP (0.49) | XIAPDPP4FAPDPP7PREP | |
| SCHEMBL30721586 | 0.84 | ACE (0.51) | XIAPDPP4FAPDPP7PREP | |
| SCHEMBL30051612 | 0.84 | DPP4 (0.51) | XIAPDPP4FAPDPP7PREP | |
| SCHEMBL31181299 | 0.83 | CPA1 (0.47) | XIAPFAPPREPELANEACE | |
| SCHEMBL29655765 | 0.83 | DPP4 (0.52) | XIAPDPP4FAPDPP7PREP | |
| SCHEMBL9622786 | 0.83 | PREP (0.49) | XIAPDPP4FAPPREPDPP8 | |
| SCHEMBL9002891 | 0.83 | PREP (0.57) | XIAPDPP4FAPPREPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127144-A | PRODUCING HETEROLOGOUS PROTEINS BY INCUBATING STREPTOMYCES CELL TRANSFORMED WITH NUCLEIC ACID EXPRESSION CONSTRUCT IN PRESENCE OF PEPTIDE-SUSBSTITUTED CHLOROMETHYLKETONE AMINOPEPTIDASE INHIBITOR HAVING DEFINED STRUCTURE | CANGENE CORPORATION (CA) | 2000-10-03 | — | — | US | disclosed |
| US-5856166-A | ENDOGENOUS TO STREPTOMYCES CELLS DEGRADES HETEROLOGOUS SECRETED FROM STREPTOMYCES HOST CELL | CANGENE CORPORATION (CA) | 1999-01-05 | — | — | US | disclosed |
| US-5616485-A | GENETIC ENGINEERING | CANGENE CORPORATION (CA) | 1997-04-01 | — | — | US | disclosed |
| EP-0731841-A1 | PROTEASES FROM STREPTOMYCES AND USE THEREOF IN PROTEIN EXPRESSION SYSTEMS | Cangene Corporation (CA) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995017512-A2 | PROTEASES FROM STREPTOMYCES AND USE THEREOF IN PROTEIN EXPRESSION SYSTEMS | CANGENE CORPORATION (CA) | 1995-06-29 | — | — | WO | disclosed |