Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 7/20 | 0.41 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939748 | 0.86 | CA1 (0.49) | CA1CA2CA9CA12CA7 | |
| SCHEMBL940697 | 0.84 | CA1 (0.47) | CA1CA2CA9CA12CA7 | |
| SCHEMBL941635 | 0.83 | CA12 (0.46) | CA1CA2CA9CA12CA7 | |
| SCHEMBL19619490 | 0.82 | CA1 (0.48) | CA1CA2CA9CA12CA7 | |
| SCHEMBL19619497 | 0.81 | CA12 (0.47) | CA1CA2CA9CA12CA7 | |
| SCHEMBL8001625 | 0.80 | CA1 (0.43) | CA1CA2CA9CA12CA7 | |
| SCHEMBL941153 | 0.77 | MMP2 (0.54) | CA1CA2CA9CA12CA7 | |
| SCHEMBL941157 | 0.75 | MMP2 (0.52) | CA1CA2CA9CA12CA7 | |
| SCHEMBL942129 | 0.74 | GAA (0.44) | CA1CA2CA9CA12PDIA6 | |
| SCHEMBL939758 | 0.74 | TSHR (0.51) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118292-A1 | ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |