Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17919040 | 1.00 | MAPT (0.44) | MAPTPKMCXCR3ALDH1A1HTR2C | |
| SCHEMBL17919092 | 0.82 | MAPT (0.43) | MAPTPKMALDH1A1HTR2CPRCP | |
| SCHEMBL31449994 | 0.82 | MAPT (0.46) | MAPTPKMALDH1A1MAPK1MEN1 | |
| SCHEMBL7896902 | 0.80 | MAPT (0.43) | MAPTPKMMAPK1MEN1KMT2A | |
| SCHEMBL31449814 | 0.79 | MAPT (0.44) | MAPTPKMHTR2CMAPK1DPP4 | |
| SCHEMBL31449926 | 0.79 | MAPT (0.52) | MAPTPKMALDH1A1MEN1KMT2A | |
| SCHEMBL21036775 | 0.78 | FPR1 (0.44) | HTR2CPRCP | |
| SCHEMBL21036774 | 0.78 | FPR1 (0.44) | HTR2CPRCP | |
| SCHEMBL31449855 | 0.77 | SMN1; SMN2 (0.47) | MAPTPKMALDH1A1MAPK1MEN1 | |
| Trifluoroacetic Acid SCHEMBL31449713 | 0.77 | MAPT (0.41) | MAPTPKMALDH1A1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009131975-A1 | PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE | SCHERING CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |