Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | LPL | P06858 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154628 | 0.98 | LTA4H (0.53) | KIF11LTA4HKCNH2TP53CYP17A1 | |
| SCHEMBL10472463 | 0.85 | ERBB2 (0.46) | KIF11LTA4HKCNH2TP53 | |
| SCHEMBL7455134 | 0.84 | LTA4H (0.67) | LTA4HKCNH2CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL154838 | 0.84 | CNR2 (0.50) | LTA4HKCNH2TP53ERN1CYP2E1 | |
| SCHEMBL16546585 | 0.84 | LTA4H (0.48) | LTA4HKCNH2TP53CYP17A1CYP11B1 | |
| SCHEMBL338810 | 0.82 | LTA4H (0.70) | LTA4HKCNH2CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL935372 | 0.82 | ERN1 (0.49) | LTA4HKCNH2TP53PDK2ERN1 | |
| SCHEMBL20368756 | 0.81 | LTA4H (0.46) | LTA4HKCNH2TP53CYP17A1CYP11B1 | |
| SCHEMBL28222643 | 0.80 | ERN1 (0.51) | KIF11LTA4HKCNH2CYP17A1CYP11B1 | |
| SCHEMBL1623633 | 0.79 | LTA4H (0.52) | KIF11LTA4HKCNH2TP53CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |