Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528410 | 0.80 | ALDH1A1 (0.43) | TDP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL11049111 | 0.78 | TSHR (0.41) | MEN1KMT2ATDP1MAPTPOLB | |
| SCHEMBL28545972 | 0.77 | ALDH1A1 (0.36) | MEN1KMT2ATDP1MAPTPOLB | |
| SCHEMBL6703354 | 0.77 | TDP1 (0.41) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL8069993 | 0.74 | ALDH1A1 (0.47) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL27670471 | 0.73 | TDP1 (0.41) | MEN1KMT2ATDP1MAPTPOLB | |
| SCHEMBL6963561 | 0.73 | MAPT (0.41) | MEN1KMT2ATDP1MAPTPOLB | |
| SCHEMBL27832802 | 0.71 | MEN1 (0.53) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL9703411 | 0.68 | TSHR (0.54) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL203912 | 0.68 | TSHR (0.44) | MEN1KMT2AUSP2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093821-A | MAKING 6-(PHENYL OR HETEROARYL)-1,2-DIHYDRO-N-1-PROTECTED QUINOLINE BY REACTING THE CORRESPONDING 6-HALO-DERIVATIVE WITH AN ORGANOBORATE AND ACID TREATMENT TO FORM THE 6-BORO-DERIVATIVE, COUPLING WITH PHENYL OR HETEROARYL HALIDE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2000-07-25 | — | — | US | disclosed |