Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.42 |
| ▸ | MERTK | Q12866 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001931 | 0.84 | MERTK (0.40) | KDM1AMAOBMAOAKCNA5ADRB2 | |
| SCHEMBL10145444 | 0.77 | KCNA5 (0.56) | KCNA5ADRB2ADRB1MERTKAXL | |
| SCHEMBL10145457 | 0.77 | KCNA5 (0.56) | KCNA5ADRB2ADRB1MERTKAXL | |
| SCHEMBL12832833 | 0.77 | KCNA5 (0.53) | KCNA5ADRB2ADRB1MERTKAXL | |
| SCHEMBL27701237 | 0.76 | KCNA5 (0.53) | KCNA5ADRB2ADRB1MERTKAXL | |
| SCHEMBL21359781 | 0.75 | PSEN1 (0.53) | KCNA5 | |
| SCHEMBL18739483 | 0.74 | KCNA5 (0.54) | KCNA5ADRB2ADRB1MERTKAXL | |
| SCHEMBL12667445 | 0.74 | KCNA5 (0.54) | KCNA5ADRB2ADRB1MERTKAXL | |
| SCHEMBL12667447 | 0.74 | KCNA5 (0.54) | KCNA5ADRB2ADRB1MERTKAXL | |
| SCHEMBL20024566 | 0.74 | KCNA5 (0.54) | KCNA5ADRB2ADRB1MERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108117-A1 | MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF 177 | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | WO | disclosed |