SCHEMBL8003012

SCHEMBL8003012

CCCCOC(=O)c1cccc(CC#N)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.50
CYP2C19 P33261 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
CYP2C9 P11712 2/20 0.50
NPC1 O15118 1/20 0.50
HPGD P15428 1/20 0.50
RAB9A P51151 1/20 0.50
ESR1 P03372 8/20 0.49
CYP4F2 P78329 1/20 0.49
CYP4A11 Q02928 1/20 0.49
TSHR P16473 4/20 0.49
LMNA P02545 2/20 0.49
MAPK1 P28482 2/20 0.49
CYP2D6 P10635 1/20 0.49
NR1H2 P55055 1/20 0.49
RNASEL Q05823 1/20 0.49
CYP3A4 P08684 2/20 0.48
PDE4D Q08499 1/20 0.48
TDP1 Q9NUW8 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1198816 0.86 CYP4F2 (0.61) SMN1; SMN2NPC1RAB9ACYP4F2CYP4A11
SCHEMBL10706157 0.86 L3MBTL1 (0.57) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
SCHEMBL15344564 0.83 CYP4F2 (0.61) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
SCHEMBL9770912 0.83 CYP4F2 (0.57) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
SCHEMBL14919190 0.83 L3MBTL1 (0.55) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
SCHEMBL7995893 0.83 ESR1 (0.62) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
SCHEMBL111861 0.82 L3MBTL1 (0.64) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
SCHEMBL27537771 0.82 TSHR (0.54) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
Lithium SCHEMBL30876327 0.81 L3MBTL1 (0.62) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9
SCHEMBL7189257 0.81 L3MBTL1 (0.62) CYP1A2CYP2C19SMN1; SMN2L3MBTL1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009113320-A1 MMP INHIBITOR 株式会社ヤクルト本社 (JP) 2009-09-17 WO disclosed