Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 17/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 17/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196234 | 0.86 | HIF1A (0.50) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL7835766 | 0.84 | HIF1A (0.49) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL9201152 | 0.82 | HIF1A (0.53) | HIF1AEPAS1EP300 | |
| SCHEMBL9203941 | 0.81 | HIF1A (0.57) | HIF1AEPAS1EP300 | |
| SCHEMBL8813555 | 0.81 | HIF1A (0.49) | HIF1AEPAS1ALDH1A1EP300 | |
| SCHEMBL7837529 | 0.79 | HIF1A (0.56) | HIF1AEPAS1EP300 | |
| SCHEMBL9335695 | 0.77 | HIF1A (0.53) | HIF1AEPAS1EP300 | |
| SCHEMBL9293857 | 0.76 | HIF1A (0.43) | HIF1AEPAS1EP300 | |
| SCHEMBL7826382 | 0.76 | HIF1A (0.50) | HIF1AEPAS1ALDH1A1CA12CA1 | |
| SCHEMBL7826302 | 0.76 | HIF1A (0.60) | HIF1AEPAS1CA12CA9EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000021957-A1 | BENZOPYRANS HAVING POTASSIUM CHANNEL OPENING ACTIVITY | NOVARTIS AG (CH) | 2000-04-20 | — | — | WO | disclosed |