Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079821 | 1.00 | ADRA2A (0.43) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8076366 | 0.94 | ADRA2A (0.42) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8002134 | 0.93 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8004160 | 0.93 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8000729 | 0.93 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8000725 | 0.93 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8004156 | 0.93 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8002137 | 0.93 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7999949 | 0.92 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7999954 | 0.92 | ADRA2A (0.40) | ADRA2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114352-A | Quinolinone derivative and anti-allergic agent with said quinolinone derivative as the active ingredient | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2000-09-05 | — | — | US | disclosed |
| EP-0785190-B1 | Quinolinone derivative and antiallergic agent with said quinolinone derivative as the active ingredient | DAINIPPON INK & CHEMICALS (JP) | 2000-08-16 | — | — | EP | disclosed |
| US-5942521-A | Quinolinone derivative and anti-allergic agent with said quinolinone derivative as the active ingredient | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1999-08-24 | — | — | US | disclosed |
| EP-0785190-A2 | Quinolinone derivative and antiallergic agent with said quinolinone derivative as the active ingredient | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1997-07-23 | — | — | EP | disclosed |