Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17483813 | 0.84 | SMN1; SMN2 (0.36) | MAPTNOS3NOS1NOS2LMNA | |
| SCHEMBL14851433 | 0.84 | AKT1 (0.35) | F2PRSS1PRSS3ESR1MAPT | |
| SCHEMBL14396441 | 0.76 | CYP19A1 (0.39) | CYP19A1MASP2PLAUTHPOF2 | |
| SCHEMBL11933762 | 0.74 | MASP2 (0.34) | CYP19A1MASP2PLAUTHPOF2 | |
| SCHEMBL10683406 | 0.70 | MASP2 (0.41) | CYP19A1MASP2PLAUTHPOF2 | |
| SCHEMBL14541399 | 0.68 | AKT1 (0.38) | ESR1NPC1MAPTRAB9A | |
| SCHEMBL25467855 | 0.67 | DEGS1 (0.39) | LMNA | |
| SCHEMBL16433594 | 0.66 | CYP19A1 (0.43) | CYP19A1MASP2PLAUTHPOF2 | |
| SCHEMBL21557137 | 0.66 | CYP19A1 (0.39) | CYP19A1MASP2PLAUTHPOF2 | |
| SCHEMBL24203475 | 0.65 | MEN1 (0.30) | ESR1MAPTLMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |