Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.51 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017826 | 0.87 | MDM2 (0.59) | MDM2KMT2APKMSMN1; SMN2TAAR1 | |
| SCHEMBL8020585 | 0.85 | MDM2 (0.66) | MDM2KMT2APKMSMN1; SMN2TAAR1 | |
| SCHEMBL4448022 | 0.82 | ALDH1A1 (0.65) | KMT2AATMMAPTTP53MEN1 | |
| SCHEMBL8013378 | 0.81 | NPC1 (0.68) | KMT2ATAAR1ATMMAPTMEN1 | |
| SCHEMBL5851814 | 0.80 | MDM2 (0.76) | MDM2KMT2APKMSMN1; SMN2TAAR1 | |
| SCHEMBL4548130 | 0.80 | CNR1 (0.58) | KMT2ASMN1; SMN2ATMMAPTTP53 | |
| SCHEMBL16857521 | 0.80 | MAPT (0.63) | KMT2APKMATMMAPTTP53 | |
| SCHEMBL10020286 | 0.80 | MDM2 (1.00) | MDM2KMT2APKMSMN1; SMN2TAAR1 | |
| SCHEMBL5640290 | 0.78 | NAMPT (0.53) | MDM2KMT2APKMSMN1; SMN2RAB9A | |
| SCHEMBL31610791 | 0.78 | TYK2 (0.59) | MDM2KMT2APKMSMN1; SMN2NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135335-B1 | N-(2,6-DISUBSTITUTED AROMATIC)-N'-PYRIDINYL UREAS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | WARNER-LAMBERT COMPANY (US) | 1989-11-08 | — | — | EP | claimed |
| US-4629731-A | Anticonvulsant N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas | WARNER-LAMBERT COMPANY (US) | 1986-12-16 | — | — | US | claimed |
| EP-0135335-A2 | N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1985-03-27 | — | — | EP | claimed |
| US-6133299-A | ADMINISTERING TO A MAMMAL A COMPOUND SELECTED FROM RALITOLINE, PHENYTOIN, LAMOTRIGINE, CARBAMAZEPINE, LIDOCAINE OR TETRODOTOXIN; TREATING DISEASE SUCH AS STROKE, ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, PARKINSON'S DISEASE | WARNER-LAMBERT COMPANY (US) | 2000-10-17 | — | — | US | disclosed |
| WO-1994018972-A2 | METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS USING N-(2,6-DISUBSTITUTED AROMATIC)-N'-PYRIDINYL UREAS AND OTHER ANTICONVULSANT COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1994-09-01 | — | — | WO | disclosed |
| US-4962116-A | ANTICONVULSANTS, ANTIEPILEPTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0135335-B1 | N-(2,6-DISUBSTITUTED AROMATIC)-N'-PYRIDINYL UREAS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | WARNER-LAMBERT COMPANY (US) | 1989-11-08 | — | — | EP | disclosed |
| US-4629731-A | Anticonvulsant N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas | WARNER-LAMBERT COMPANY (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0135335-A2 | N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1985-03-27 | — | — | EP | disclosed |