SCHEMBL8005080

SCHEMBL8005080

COC(=O)c1cc(C(=O)NCCN(C)C)cc(-c2cc(Cl)ccc2Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.51
HPGD P15428 2/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
CYP1A2 P05177 1/20 0.46
HRH4 Q9H3N8 2/20 0.45
HRH3 Q9Y5N1 2/20 0.45
ALDH1A1 P00352 1/20 0.42
YES1 P07947 1/20 0.42
PDGFRB P09619 1/20 0.42
SRC P12931 1/20 0.42
LMNA P02545 1/20 0.41
KDR P35968 1/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
MALT1 Q9UDY8 1/20 0.41
FYN P06241 1/20 0.41
ADORA1 P30542 1/20 0.41
PDE4B Q07343 1/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7995813 0.99 KMT2A (0.50) KMT2AHPGDSMN1; SMN2CYP1A2HRH4
SCHEMBL8007800 0.94 ADORA1 (0.47) KMT2AHPGDSMN1; SMN2ALDH1A1MALT1
SCHEMBL7995581 0.89 MCHR1 (0.46) KMT2ASMN1; SMN2CYP1A2ALDH1A1LMNA
Hydrochloric Acid SCHEMBL8004278 0.89 SMN1; SMN2 (0.47) KMT2AHPGDSMN1; SMN2CYP1A2HRH4
Hydrochloric Acid SCHEMBL8005263 0.89 SMN1; SMN2 (0.46) KMT2AHPGDSMN1; SMN2CYP1A2ALDH1A1
Hydrochloric Acid SCHEMBL8663971 0.88 KMT2A (0.51) KMT2AHPGDSMN1; SMN2HRH4HRH3
Hydrochloric Acid SCHEMBL8663603 0.88 CYP2D6 (0.47) KMT2AHPGDSMN1; SMN2CYP1A2ALDH1A1
Hydrochloric Acid SCHEMBL8004367 0.86 MRGPRX4 (0.52) KMT2AHPGDSMN1; SMN2CYP1A2ALDH1A1
SCHEMBL8664616 0.85 MAPK1 (0.47) HPGDSMN1; SMN2ALDH1A1LMNAADORA1
SCHEMBL8009311 0.84 KMT2A (0.46) KMT2AHPGDSMN1; SMN2CYP1A2HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6017917-A Guanidine derivatives FUJISAWA PHARAMCEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed
EP-0876338-A1 GUANIDINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997025310-A1 GUANIDINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-17 WO disclosed