⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907294 | 0.98 | SOS1 (0.30) | — | |
| Ammonia Solution, Strong SCHEMBL28132440 | 0.95 | — | — | |
| SCHEMBL28213926 | 0.88 | — | — | |
| Formamide SCHEMBL29115926 | 0.86 | — | — | |
| SCHEMBL1114730 | 0.85 | SOS1 (0.34) | — | |
| SCHEMBL576793 | 0.85 | SOS1 (0.34) | — | |
| SCHEMBL27329691 | 0.82 | GNAI3 (0.31) | — | |
| Pyridine SCHEMBL28104401 | 0.82 | TSHR (0.30) | — | |
| Pyridine SCHEMBL28098053 | 0.80 | — | — | |
| Pyridine SCHEMBL28319894 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112654608-B | Fused ring compound having urea structure | 桑福德伯纳姆普利斯医学发现研究所 | 2024-05-07 | — | — | CN | disclosed |
| CN-112654608-A | Condensed ring compounds having urea structure | 桑福德伯纳姆普利斯医学发现研究所 | 2021-04-13 | — | — | CN | disclosed |
| US-9242945-B2 | Substituted 2-benzylidene-2H-benzo[b][1,4]thiazin-3(4H)-ones, derivatives thereof, and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2016-01-26 | — | — | US | disclosed |
| CN-103189501-B | Composition for maintaining platelet function | UNIV TOKYO | 2015-04-22 | — | — | CN | disclosed |
| US-20140086941-A1 | SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2014031571-A1 | TREATMENT OF VIRAL INFECTIONS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-02-27 | — | — | WO | disclosed |
| CN-103189501-A | Composition for maintaining platelet function | UNIV TOKYO | 2013-07-03 | — | — | CN | disclosed |
| WO-2012166586-A1 | SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-12-06 | — | — | WO | disclosed |
| CN-102321024-A | Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof | ARENA PHARM INC | 2012-01-18 | — | — | CN | disclosed |
| CN-102311378-A | Fused pyrazole derivatives and uses thereof in methods of treatment of metabolic-related disorders | ARENA PHARM INC | 2012-01-11 | — | — | CN | disclosed |
| CN-101087765-A | Fused pyrazole derivatives and their use in methods of treating metabolic-related disorders | ARENA PHARM INC (US) | 2007-12-12 | — | — | CN | disclosed |
| CN-1273579-A | Anthranilic acid analogs | AMERICAN HOME PROD (US) | 2000-11-15 | — | — | CN | disclosed |
| EP-1026155-A1 | VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-08-09 | — | — | EP | disclosed |
| US-6054597-A | Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors | DUPONT PHARMACEUTICALS (US) | 2000-04-25 | — | — | US | disclosed |
| US-5710286-A | Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-01-20 | — | — | US | disclosed |
| WO-1996000728-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF CYCLIC UREA HIV PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-01-11 | — | — | WO | disclosed |
| US-5466797-A | Intermediates for the preparation of cyclic urea | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-11-14 | — | — | US | disclosed |