SCHEMBL8005897

SCHEMBL8005897

C=CCCCCCCCS(C)(=O)=O

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.48
MAPT P10636 3/20 0.41
ABCC4 O15439 1/20 0.41
ALDH1A1 P00352 5/20 0.41
LMNA P02545 3/20 0.41
TP53 P04637 1/20 0.38
LPAR3 Q9UBY5 2/20 0.36
LPAR2 Q9HBW0 1/20 0.36
TRPA1 O75762 2/20 0.34
USP2 O75604 2/20 0.33
CYP3A4 P08684 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
RECQL P46063 1/20 0.33
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8077519 1.00 TSHR (0.48) TSHRMAPTABCC4ALDH1A1LMNA
SCHEMBL8072036 1.00 TSHR (0.48) TSHRMAPTABCC4ALDH1A1LMNA
SCHEMBL1118622 1.00 TSHR (0.48) TSHRMAPTABCC4ALDH1A1LMNA
SCHEMBL1607801 0.98 TSHR (0.44) TSHRMAPTABCC4ALDH1A1LMNA
SCHEMBL1118529 0.98 TSHR (0.44) TSHRMAPTABCC4ALDH1A1LMNA
SCHEMBL7819862 0.90
SCHEMBL19644547 0.80 TSHR (0.46) TSHRMAPTABCC4ALDH1A1LMNA
SCHEMBL20972793 0.80 TSHR (0.46) TSHRMAPTABCC4ALDH1A1LMNA
SCHEMBL6601699 0.79
SCHEMBL9185106 0.79 ALDH1A1 (0.50) TSHRALDH1A1LMNATP53USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6133274-A TREATING DISEASE MEDIATED BY INTRACELLULAR SIGNALING THROUGH ONE OR TWO SPECIFIC INTRACELLULAR SIGNALING PATHWAYS; A XANTHINYL HAVING AT LEAST ONE NITROGEN SUBSTITUTED BY AN HYDROXYALKYL; ANTITUMOR,-CARCINOGENIC,-ARTHRITIC AGENTS CELL THERAPEUTICS, INC. (US) 2000-10-17 US disclosed
US-5804584-A USEFUL IN TREATING INDIVIDUALS HAVING A DISEASE OR TREATMENT-INDUCED TOXICITY, MEDIATED BY SECOND MESSENGER ACTIVITY CELL THERAPEUTICS, INC. (US) 1998-09-08 US disclosed
US-5780476-A ADMINISTERING TO TREAT INFLAMMATORY DISEASE AND RHEUMATOID ARTHITIS CELL THERAPEUTICS, INC. (US) 1998-07-14 US disclosed
EP-0669825-A4 HYDROXYL-CONTAINING COMPOUNDS. CELL THERAPEUTICS INC (US) 1996-04-03 EP disclosed
US-5473070-A Cell stimulus response modulators CELL THERAPEUTICS, INC. (US) 1995-12-05 US disclosed
EP-0669825-A1 HYDROXYL-CONTAINING COMPOUNDS CELL THERAPEUTICS, INC. (US) 1995-09-06 EP disclosed
WO-1994011001-A1 HYDROXYL-CONTAINING COMPOUNDS CELL THERAPEUTICS, INC. (US) 1994-05-26 WO disclosed