Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8002399 | 0.92 | FAAH (0.62) | FAAHMAPK10KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL8008392 | 0.83 | FAAH (0.57) | FAAHKDM4ESMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL7992747 | 0.80 | FAAH (0.51) | FAAHMAPK10KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL8003074 | 0.80 | FAAH (0.61) | FAAHKDM4ESMN1; SMN2L3MBTL1POLB | |
| SCHEMBL7993064 | 0.80 | FAAH (0.76) | FAAHKDM4ESMN1; SMN2L3MBTL1POLB | |
| SCHEMBL8005332 | 0.78 | FAAH (0.61) | FAAHMAPK10KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL8001993 | 0.77 | FAAH (0.52) | FAAHKDM4ESMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL8001996 | 0.77 | FAAH (0.64) | FAAHKDM4ESMN1; SMN2L3MBTL1POLB | |
| SCHEMBL7994178 | 0.77 | FAAH (0.66) | FAAHKDM4ESMN1; SMN2L3MBTL1POLB | |
| SCHEMBL8008516 | 0.76 | FAAH (0.71) | FAAHKDM4ESMN1; SMN2L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152025-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |