Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.71 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.71 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12640606 | 0.87 | GRIN1 (0.82) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 | |
| SCHEMBL2017364 | 0.83 | GRIN1 (1.00) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 | |
| SCHEMBL8013074 | 0.82 | GRIN1 (0.72) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 | |
| SCHEMBL2020842 | 0.82 | GRIN1 (1.00) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 | |
| N-Desmethyldofetilide SCHEMBL7853191 | 0.81 | KCNH2 (0.64) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 | |
| SCHEMBL8018366 | 0.80 | GRIN1 (0.71) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 | |
| SCHEMBL6571893 | 0.80 | KCNH2 (0.78) | KCNH2GRIN1GRIN2BCYP1A2CYP3A4 | |
| SCHEMBL1422219 | 0.79 | GRIN1 (1.00) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL6573634 | 0.79 | KCNH2 (0.77) | KCNH2GRIN1GRIN2BCYP1A2CYP3A4 | |
| SCHEMBL12640641 | 0.77 | GRIN1 (1.00) | KCNH2GRIN1GRIN2BSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420680-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-20110160223-A1 | NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders | EMORY UNIVERSITY | 2011-06-30 | — | — | US | disclosed |
| WO-2009137843-A2 | NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | EMORY UNIVERSITY (US) | 2009-11-12 | — | — | WO | disclosed |
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | EMORY UNIVERSITY | 2009-10-08 | — | — | US | disclosed |
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | EMORY UNIVERSITY | 2009-10-08 | — | — | US | disclosed |
| WO-2009006437-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | GRIN1, GRIN2C, GRIK1 | KCNH2 137/4885GRIN1 1/4885GRIN2B 7/4885 |
| US-20110160223-A1 | NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders | GRIN2A, GRIN2B, GRIN1 | KCNH2 469/4885GRIN1 3/4885GRIN2B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.