Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.77 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.77 |
| ▸ | F10 | P00742 | 5/20 | 0.77 |
| ▸ | PLG | P00747 | 4/20 | 0.77 |
| ▸ | PROC | P04070 | 2/20 | 0.77 |
| ▸ | PLAT | P00750 | 4/20 | 0.64 |
| ▸ | F9 | P00740 | 2/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.59 |
| ▸ | F7 | P08709 | 1/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478579 | 1.00 | F11 (0.77) | F11KLKB1F10PLGPROC | |
| SCHEMBL478577 | 1.00 | F11 (0.77) | F11KLKB1F10PLGPROC | |
| SCHEMBL478601 | 0.94 | F11 (0.69) | F11KLKB1F10PLGPROC | |
| SCHEMBL12945537 | 0.93 | F11 (0.67) | F11KLKB1F10PLGPROC | |
| SCHEMBL478426 | 0.91 | F11 (0.78) | F11KLKB1F10PLGPROC | |
| SCHEMBL478423 | 0.91 | F11 (0.78) | F11KLKB1F10PLGPROC | |
| SCHEMBL8006336 | 0.91 | F11 (0.78) | F11KLKB1F10PLGPROC | |
| SCHEMBL478717 | 0.88 | F11 (0.78) | F11KLKB1F10PLGPROC | |
| SCHEMBL478718 | 0.88 | F11 (0.78) | F11KLKB1F10PLGPROC | |
| SCHEMBL8005631 | 0.87 | F11 (1.00) | F11KLKB1F10PLGPROC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265601-B1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2009114677-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-17 | — | — | WO | disclosed |