Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 7/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8006938 | 0.91 | TRPV4 (0.53) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL8004239 | 0.90 | TRPV4 (0.40) | TRPV4CTSSCTSBCTSKCCR1 | |
| SCHEMBL8012364 | 0.88 | TRPV4 (0.49) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL8012366 | 0.88 | TRPV4 (0.54) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL4059049 | 0.87 | TRPV4 (0.53) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL8006169 | 0.82 | TRPV4 (0.50) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL8008220 | 0.82 | TRPV4 (0.66) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL8008215 | 0.81 | TRPV4 (0.65) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL8006952 | 0.81 | TRPV4 (0.74) | TRPV4TAS1R3TAS1R1CTSSCTSB | |
| SCHEMBL8004713 | 0.81 | TRPV4 (0.74) | TRPV4TAS1R3TAS1R1CTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |