Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6354061 | 0.89 | ALDH1A1 (0.42) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL13979716 | 0.85 | MAPT (0.56) | MAPTKDM4EMEN1RAB9AKMT2A | |
| Iodide SCHEMBL3053673 | 0.84 | MAPT (0.58) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL8797230 | 0.83 | KDM4E (0.36) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL4120155 | 0.81 | MAPT (0.48) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL8861440 | 0.81 | MAPT (0.33) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL11599645 | 0.79 | KDM4E (0.42) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL8861444 | 0.78 | KDM4E (0.34) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL2030271 | 0.78 | MAPT (0.54) | MAPTKDM4EMEN1RAB9AKMT2A | |
| SCHEMBL7256860 | 0.78 | KDM4E (0.43) | MAPTKDM4EMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738786-B2 | Dyes for labelling molecular ligands | ILLUMINA CAMBRIDGE LIMITED (GB) | 2017-08-22 | — | — | US | disclosed |
| EP-2758475-B1 | DYES FOR LABELLING MOLECULAR LIGANDS | ILLUMINA CAMBRIDGE LTD (GB) | 2017-04-26 | — | — | EP | disclosed |
| US-20160355683-A1 | DYES FOR LABELLING MOLECULAR LIGANDS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-9376568-B2 | Dyes for labelling molecular ligands | ILLUMINA CAMBRIDGE LIMITED (GB) | 2016-06-28 | — | — | US | disclosed |
| US-20150274976-A1 | DYES FOR LABELLING MOLECULAR LIGANDS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-10-01 | — | — | US | disclosed |
| US-9085698-B2 | Dyes for labelling molecular ligands | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-07-21 | — | — | US | disclosed |
| US-20140323741-A1 | DYES FOR LABELLING MOLECULAR LIGANDS | ILLUMINA CAMBRIDGE LTD. (GB) | 2014-10-30 | — | — | US | disclosed |
| EP-2758475-A1 | DYES FOR LABELLING MOLECULAR LIGANDS | Illumina Cambridge Limited (GB) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013041117-A1 | DYES FOR LABELLING MOLECULAR LIGANDS | ILLUMINA CAMBRIGDE LTD. (GB) | 2013-03-28 | — | — | WO | disclosed |
| US-6143434-A | HIGH LUMINANCE AND A HIGH LUMINESCENT EFFICIENCY AT A LOW DRIVING VOLTAGE AND HAS EXCELLENT STABILITY IN REPETITIONS OF USE | FUJI PHOTO FILM CO., LTD. (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0527494-B1 | Compositon containing rhodacyanine dyes for treating cancer | FUJI PHOTO FILM CO LTD (JP) | 1996-11-06 | — | — | EP | disclosed |
| US-5360803-A | Rhodocyanine dyes | DAN FARBER CANCER INSTITUTE (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0527494-A1 | Compositon containing rhodacyanine dyes for treating cancer | Fuji Photo Film Co., Ltd. (JP) | 1993-02-17 | — | — | EP | disclosed |