Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004381 | 1.00 | DRD2 (0.51) | DRD2DRD3DPP4TBXA2RRORC | |
| SCHEMBL2004384 | 1.00 | DRD2 (0.51) | DRD2DRD3DPP4TBXA2RRORC | |
| SCHEMBL2004378 | 1.00 | DRD2 (0.51) | DRD2DRD3DPP4TBXA2RRORC | |
| SCHEMBL3798157 | 0.90 | CARM1 (0.43) | DRD2DRD3DPP4MEN1KMT2A | |
| SCHEMBL2006344 | 0.88 | DRD2 (0.42) | DRD2DRD3DPP4MEN1KMT2A | |
| SCHEMBL2006342 | 0.88 | DRD2 (0.42) | DRD2DRD3DPP4MEN1KMT2A | |
| SCHEMBL2006348 | 0.88 | DRD2 (0.42) | DRD2DRD3DPP4MEN1KMT2A | |
| SCHEMBL8010511 | 0.88 | DRD2 (0.42) | DRD2DRD3DPP4MEN1KMT2A | |
| SCHEMBL12413234 | 0.85 | CARM1 (0.42) | DRD2DRD3DPP4KMT2ACARM1 | |
| SCHEMBL2005531 | 0.83 | DRD1 (0.50) | DRD2DRD3ALOX15TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240492-B1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | ORGANON NV (NL) | 2011-10-05 | — | — | EP | disclosed |
| WO-2009087058-A1 | PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS | N.V. ORGANON (NL) | 2009-07-16 | — | — | WO | disclosed |