Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805305 | 0.72 | ALDH1A1 (0.35) | ALDH1A1MAPTHPGDGAAMEN1 | |
| SCHEMBL800052 | 0.68 | ALDH1A1 (0.32) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL10428044 | 0.66 | POLB (0.33) | ALDH1A1MAPTHPGD | |
| SCHEMBL18944225 | 0.65 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL12341078 | 0.60 | — | — | |
| SCHEMBL12445270 | 0.60 | ALDH1A1 (0.32) | ALDH1A1MAPTHPGDGAAMEN1 | |
| SCHEMBL20322375 | 0.58 | — | — | |
| SCHEMBL780956 | 0.57 | — | — | |
| SCHEMBL1515964 | 0.57 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDGAAMEN1 | |
| SCHEMBL11244350 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-9604958-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2017-03-28 | — | — | US | disclosed |
| US-9604958-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | ALDH1A1 595/4885MAPT 4004/4885HPGD 101/4885 |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | ALDH1A1 595/4885MAPT 4004/4885HPGD 101/4885 |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | ALDH1A1 595/4885MAPT 4004/4885HPGD 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.