Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050630 | 0.87 | PDCD1 (0.52) | AKR1C3AKR1C2EPHX2AKR1C4AKR1C1 | |
| SCHEMBL7946481 | 0.83 | CYP11B1 (0.48) | CYP11B1CYP11B2PDCD1CD274MEN1 | |
| SCHEMBL1992428 | 0.81 | EPHX2 (0.58) | EPHX2 | |
| SCHEMBL7941906 | 0.81 | SCN9A (0.42) | AKR1C3AKR1C2AKR1C4AKR1C1AKR1B10 | |
| SCHEMBL7941955 | 0.81 | AKR1C3 (0.45) | AKR1C3AKR1C2EPHX2AKR1C4AKR1C1 | |
| SCHEMBL7946478 | 0.81 | CYP1A1 (0.55) | CYP11B1CYP11B2PDCD1CD274SMN1; SMN2 | |
| SCHEMBL15719330 | 0.80 | FFAR1 (0.48) | CYP11B1CYP11B2PDCD1CD274 | |
| SCHEMBL7944717 | 0.80 | CYP11B1 (0.45) | CYP11B1CYP11B2PDCD1CD274MEN1 | |
| SCHEMBL14525154 | 0.78 | AR (0.41) | AKR1C3AKR1C2AKR1C4AKR1C1CYP11B2 | |
| SCHEMBL8021656 | 0.77 | S1PR1 (0.50) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |