Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | FASN | P49327 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946481 | 0.87 | CYP11B1 (0.48) | CYP11B1CYP11B2KDM4EALDH1A1PDCD1 | |
| SCHEMBL8024217 | 0.86 | PDCD1 (0.56) | CYP11B1CYP11B2KDM4EALDH1A1PDCD1 | |
| SCHEMBL7946478 | 0.84 | CYP1A1 (0.55) | CYP11B1CYP11B2PDCD1CD274SMN1; SMN2 | |
| SCHEMBL15719330 | 0.80 | FFAR1 (0.48) | CYP11B1CYP11B2PDCD1CD274 | |
| SCHEMBL3994452 | 0.80 | RAB9A (0.47) | CYP11B1CYP11B2KDM4EPDCD1CD274 | |
| SCHEMBL8007347 | 0.80 | AKR1C3 (0.47) | CYP11B1CYP11B2PDCD1CD274SMN1; SMN2 | |
| SCHEMBL3127408 | 0.79 | ALDH1A1 (0.47) | CYP11B1CYP11B2KDM4EALDH1A1MEN1 | |
| SCHEMBL7945286 | 0.79 | PDCD1 (0.43) | CYP11B1CYP11B2KDM4EALDH1A1PDCD1 | |
| SCHEMBL5753110 | 0.78 | ALDH1A1 (0.54) | CYP11B1CYP11B2KDM4EALDH1A1MEN1 | |
| SCHEMBL2549337 | 0.77 | CYP2A6 (0.47) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |