Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017670 | 1.00 | OPRK1 (0.55) | OPRK1OPRM1OPRD1ALDH1A1NOTUM | |
| SCHEMBL8017672 | 1.00 | OPRK1 (0.55) | OPRK1OPRM1OPRD1ALDH1A1NOTUM | |
| SCHEMBL8021630 | 0.94 | OPRK1 (0.58) | OPRK1OPRM1OPRD1NOTUMTSHR | |
| SCHEMBL8021628 | 0.94 | OPRK1 (0.58) | OPRK1OPRM1OPRD1NOTUMTSHR | |
| SCHEMBL8019654 | 0.94 | OPRK1 (0.63) | OPRK1OPRM1OPRD1ALDH1A1NOTUM | |
| SCHEMBL8018252 | 0.94 | OPRK1 (0.63) | OPRK1OPRM1OPRD1ALDH1A1NOTUM | |
| SCHEMBL8018248 | 0.94 | OPRK1 (0.63) | OPRK1OPRM1OPRD1ALDH1A1NOTUM | |
| SCHEMBL8024600 | 0.92 | OPRK1 (0.53) | OPRK1OPRM1OPRD1ALDH1A1NOTUM | |
| SCHEMBL8020030 | 0.92 | OPRK1 (0.53) | OPRK1OPRM1OPRD1ALDH1A1NOTUM | |
| SCHEMBL8024602 | 0.92 | OPRK1 (0.53) | OPRK1OPRM1OPRD1ALDH1A1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |