Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003726 | 0.86 | JAK2 (0.53) | KDM4EJAK2MAP4K4PAK4CSF1R | |
| SCHEMBL8009410 | 0.85 | KDM4E (0.43) | NPC1RAB9AKDM4EJAK2SMN1; SMN2 | |
| SCHEMBL8012335 | 0.81 | MAP4K4 (0.55) | NPC1RAB9AKDM4EJAK2SMN1; SMN2 | |
| SCHEMBL7997517 | 0.75 | KDM4E (0.52) | NPC1RAB9AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8013138 | 0.75 | F2RL3 (0.38) | NPC1RAB9AKDM4EJAK2TP53 | |
| SCHEMBL8912927 | 0.70 | KDM4E (0.45) | NPC1RAB9AKDM4ESMN1; SMN2TP53 | |
| SCHEMBL8009917 | 0.68 | KDM4E (0.43) | NPC1RAB9AKDM4EJAK2SMN1; SMN2 | |
| SCHEMBL2968149 | 0.64 | HPGD (0.41) | NPC1RAB9AKDM4ESMN1; SMN2TP53 | |
| SCHEMBL5471370 | 0.63 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL3705440 | 0.61 | AKT1 (0.47) | NPC1RAB9AJAK2SMN1; SMN2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000009508-A1 | TRIAZOLOPYRIMIDINE DERIVATIVES | NIHON BAYER AGROCHEM K.K. (DE) | 2000-02-24 | — | — | WO | disclosed |