SCHEMBL8007489

SCHEMBL8007489

O=C1CCCC(=O)N1SC(Cl)(Cl)Cl

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
CYP3A4 P08684 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
HTT P42858 1/20 0.44
KMT2A Q03164 1/20 0.44
HIF1A Q16665 1/20 0.44
HSD17B10 Q99714 1/20 0.44
BRD4 O60885 1/20 0.31
BRD2 P25440 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9863928 0.90 ALDH1A1 (0.47) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL11747373 0.71 KMT2A (0.40) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL11410431 0.68 TSHR (0.41) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL11395605 0.67 ALDH1A1 (0.43) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL19258471 0.67 BRD4 (0.40) KMT2ABRD4BRD2
SCHEMBL11420842 0.67 ALDH1A1 (0.40) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL8331413 0.67 ALDH1A1 (0.63) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL10896351 0.67 ALDH1A1 (0.63) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL11749637 0.65 ALDH1A1 (0.47) ALDH1A1LMNATP53CYP3A4HPGD
SCHEMBL10620209 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0804455-A4 RAPID AND SENSITIVE DETECTION OF ANTIBIOTIC-RESISTANT MYCOBACTERIA USING OLIGONUCLEOTIDE PROBES SPECIFIC FOR RIBOSOMAL RNA PRECURSORS MICROPROBE CORP (US) 2000-01-12 EP disclosed
US-5770373-A Rapid and sensitive detection of antibiotic-resistant mycobacteria using oligonucleotide probe specific for ribosomal RNA precursors BECTON DICKINSON AND COMPANY (US) 1998-06-23 US disclosed
US-5712095-A Rapid and sensitive detection of antibiotic-resistant mycobacteria using oligonucleotide probes specific for ribosomal RNA precursors BECTON DICKINSON AND COMPANY (US) 1998-01-27 US disclosed
EP-0804455-A1 RAPID AND SENSITIVE DETECTION OF ANTIBIOTIC-RESISTANT MYCOBACTERIA USING OLIGONUCLEOTIDE PROBES SPECIFIC FOR RIBOSOMAL RNA PRECURSORS MICROPROBE CORPORATION (US) 1997-11-05 EP disclosed
WO-1995034574-A1 RAPID AND SENSITIVE DETECTION OF ANTIBIOTIC-RESISTANT MYCOBACTERIA USING OLIGONUCLEOTIDE PROBES SPECIFIC FOR RIBOSOMAL RNA PRECURSORS MICROPROBE CORPORATION (US) 1995-12-21 WO disclosed
US-4012359-A N-TRICHLOROMETHYL-THIOIMIDES, USEFUL IN POLYMERS FERRO CORPORATION (US) 1977-03-15 US disclosed