Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512162 | 0.89 | GRM2 (0.39) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL1511916 | 0.87 | GRM2 (0.41) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL2454633 | 0.87 | GRM2 (0.41) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL1512883 | 0.87 | GRM2 (0.42) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL8010635 | 0.86 | KDM4E (0.37) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL1512286 | 0.86 | GRM2 (0.41) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL1512463 | 0.85 | GRM2 (0.42) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL8008821 | 0.85 | GRM2 (0.37) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL8016918 | 0.85 | GRM2 (0.37) | GRM2SMN1; SMN2NPSR1KDM4EMAPT | |
| SCHEMBL12597634 | 0.84 | SMN1; SMN2 (0.44) | GRM2SMN1; SMN2NPSR1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140163-A1 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | MERCK & CO., INC. (US) | 2009-11-19 | — | — | WO | disclosed |