Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1512020 | 0.76 | CYP2D6 (0.36) | SMN1; SMN2KDM4EMAPTCYP2D6DPP4 | |
| SCHEMBL1765615 | 0.76 | GRM2 (0.53) | SMN1; SMN2NPSR1CYP2C19POLBKMT2A | |
| SCHEMBL1765689 | 0.76 | GRM2 (0.45) | SMN1; SMN2NPSR1POLBKMT2AL3MBTL1 | |
| SCHEMBL1765124 | 0.74 | GRM2 (0.40) | SMN1; SMN2NPSR1CYP2C19POLBKMT2A | |
| SCHEMBL8013052 | 0.74 | GRM2 (0.45) | SMN1; SMN2NPSR1POLBKMT2AL3MBTL1 | |
| SCHEMBL1511610 | 0.74 | CHRNA7 (0.36) | — | |
| SCHEMBL1511845 | 0.74 | LMNA (0.42) | L3MBTL1KDM4ECYP2D6 | |
| SCHEMBL1511736 | 0.73 | GRM2 (0.43) | SMN1; SMN2NPSR1POLBKMT2AL3MBTL1 | |
| SCHEMBL1512126 | 0.72 | GRM2 (0.43) | SMN1; SMN2NPSR1POLBKMT2AL3MBTL1 | |
| SCHEMBL2219155 | 0.70 | PTAFR (0.48) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140163-A1 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | MERCK & CO., INC. (US) | 2009-11-19 | — | — | WO | disclosed |