Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019357 | 1.00 | OPRM1 (0.53) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8019353 | 1.00 | OPRM1 (0.53) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8017648 | 0.95 | OPRM1 (0.50) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8017646 | 0.95 | OPRM1 (0.50) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8017665 | 0.95 | OPRM1 (0.50) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8017144 | 0.94 | OPRM1 (0.59) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8017327 | 0.94 | OPRM1 (0.56) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8024091 | 0.94 | OPRM1 (0.56) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8021437 | 0.94 | OPRM1 (0.59) | OPRM1OPRD1OPRK1HSD17B10CA1 | |
| SCHEMBL8017147 | 0.94 | OPRM1 (0.59) | OPRM1OPRD1OPRK1HSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |