Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942391 | 0.84 | STAT3 (0.58) | KDM4EALDH1A1STAT3LMNAPOLB | |
| SCHEMBL4826029 | 0.82 | TSHR (0.72) | ALDH1A1MAPK1LMNANPC1USP2 | |
| SCHEMBL939334 | 0.81 | STAT3 (0.50) | KDM4EALDH1A1STAT3LMNAPOLB | |
| SCHEMBL5076592 | 0.80 | TSHR (0.76) | ALDH1A1MAPK1LMNANPC1USP2 | |
| SCHEMBL8001580 | 0.80 | PDE4D (0.44) | KDM4EALDH1A1MAPK1STAT3LMNA | |
| SCHEMBL940166 | 0.78 | MMP2 (0.60) | ALDH1A1MAPK1STAT3LMNAMAPT | |
| SCHEMBL11115008 | 0.78 | STAT3 (0.55) | KDM4EALDH1A1STAT3LMNAPOLB | |
| SCHEMBL4826406 | 0.78 | PDE4A (0.76) | ALDH1A1MAPK1LMNANPC1USP2 | |
| SCHEMBL11116710 | 0.76 | STAT3 (0.53) | KDM4EALDH1A1STAT3LMNAPOLB | |
| SCHEMBL941153 | 0.76 | MMP2 (0.54) | MMP2TSHRTP53CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009118292-A1 | ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |