Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | GSK3B | P49841 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.64 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.64 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.64 |
| ▸ | MMP1 | P03956 | 3/20 | 0.64 |
| ▸ | MMP2 | P08253 | 2/20 | 0.64 |
| ▸ | MMP3 | P08254 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007791 | 1.00 | APP (0.78) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL1608804 | 0.92 | KDM4E (0.79) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL1608802 | 0.92 | KDM4E (0.79) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL11179981 | 0.92 | KDM4E (0.74) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL8162823 | 0.91 | APP (0.76) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL5958212 | 0.90 | APP (0.74) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL5958210 | 0.90 | APP (0.74) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL7126134 | 0.90 | APP (0.74) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL30997257 | 0.90 | APP (0.74) | APPHPGDKDM4EALDH1A1HTT | |
| SCHEMBL9550145 | 0.89 | CA12 (0.76) | APPHPGDKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046355-A | TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS | WARNER-LAMBERT COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0935597-A2 | DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5834506-A | TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS | WARNER-LAMBERT COMPANY (US) | 1998-11-10 | — | — | US | disclosed |
| WO-1998019997-A2 | DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |