Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | APP | P05067 | 7/20 | 0.78 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.74 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.74 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 4/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608804 | 1.00 | KDM4E (0.79) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL1609269 | 0.95 | KDM4E (0.79) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL1609268 | 0.95 | KDM4E (0.79) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL8007791 | 0.92 | APP (0.78) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL8007794 | 0.92 | APP (0.78) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL5848040 | 0.92 | KDM4E (0.87) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL27833553 | 0.92 | KDM4E (0.87) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL5848038 | 0.92 | KDM4E (0.87) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL6583471 | 0.91 | APP (0.69) | KDM4ELMNAAPPPTGER4PTGER3 | |
| SCHEMBL6583474 | 0.91 | APP (0.69) | KDM4ELMNAAPPPTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999029640-A2 | COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF FIBROBLAST GROWTH FACTOR | EISAI CO., LTD. (JP) | 1999-06-17 | — | — | WO | claimed |
| CN-111808031-B | Ferulic acid derivative and preparation method and application thereof | 湖南中医药大学 | 2022-01-14 | — | — | CN | disclosed |
| CN-110305102-B | 1, 3-benzodioxole natural polyphenolic acid ester compound and application thereof in reducing blood fat | 陕西中医药大学 | 2020-11-24 | — | — | CN | disclosed |
| CN-111808031-A | Ferulic acid derivative and preparation method and application thereof | 湖南中医药大学 | 2020-10-23 | — | — | CN | disclosed |
| CN-110563602-A | rosmarinic acid derivatives, and preparation method and application thereof | 南宁多灵生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | Prosetta Antiviral, Inc. (US) | 2019-02-05 | — | — | US | disclosed |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | Prosetta Antiviral, Inc. (US) | 2019-02-05 | — | — | US | disclosed |
| CN-108084030-A | A kind of cinnamic acid esters compound and its preparation method and application | 苏州沪云肿瘤研究中心股份有限公司 | 2018-05-29 | — | — | CN | disclosed |
| EP-1942101-A1 | SECRETASE INHIBITOR | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2008-07-09 | — | — | EP | disclosed |
| US-7071182-B2 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES (US) | 2006-07-04 | — | — | US | disclosed |
| US-20060122065-A1 | Amide compound and method of controlling plant disease with the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-06-08 | — | — | US | disclosed |
| US-20050277638-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBVIE INC. | 2005-12-15 | — | — | US | disclosed |
| EP-1577290-A1 | AMIDE COMPOUND AND METHOD OF CONTROLLING PLANT DISEASE WITH THE SAME | Sumitomo Chemical Company, Limited (JP) | 2005-09-21 | — | — | EP | disclosed |
| US-20050137243-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| US-6048875-A | CARDIOVASCULAR DISORDERS; REDUCING THROMBOSIS | ADIR ET COMPAGNIE (FR) | 2000-04-11 | — | — | US | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
| WO-1999029640-A2 | COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF FIBROBLAST GROWTH FACTOR | EISAI CO., LTD. (JP) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | KDM4E 289/4885LMNA 3070/4885APP 2292/4885 |
| US-20060122065-A1 | Amide compound and method of controlling plant disease with the same | CBR3, C5, CLN6 | KDM4E 3575/4885LMNA 2837/4885APP 3437/4885 |
| US-20050137243-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | KDM4E 2368/4885LMNA 3740/4885APP 1569/4885 |
| US-20050277638-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | KDM4E 2368/4885LMNA 3740/4885APP 1569/4885 |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | MAVS, EIF2AK2, POLRMT | KDM4E 289/4885LMNA 3070/4885APP 2292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.