Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007918 | 0.87 | NPC1 (0.47) | KMT2AMEN1NPC1RAB9ANPSR1 | |
| SCHEMBL7999011 | 0.86 | MET (0.51) | NPSR1METMAPK1MAPTHTR1E | |
| SCHEMBL8008245 | 0.85 | NPSR1 (0.48) | NPSR1ALDH1A1L3MBTL1METMAPK1 | |
| SCHEMBL8008159 | 0.83 | GRN (0.43) | LMNAKMT2AMEN1METKDM4E | |
| SCHEMBL8013247 | 0.82 | BRD4 (0.51) | NPSR1ALDH1A1L3MBTL1METMAPK1 | |
| SCHEMBL8008150 | 0.82 | GRN (0.41) | LMNAKMT2AMEN1METKDM4E | |
| SCHEMBL8009905 | 0.81 | MAPT (0.54) | KMT2AMEN1NPSR1METMAPK1 | |
| SCHEMBL8007462 | 0.80 | CYP2D6 (0.50) | LMNANPC1NPSR1ALDH1A1MET | |
| SCHEMBL8010517 | 0.80 | NPSR1 (0.52) | KMT2AMEN1NPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL7999906 | 0.80 | GRN (0.55) | ALDH1A1METKDM4EGUCY1B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |