SCHEMBL8008459

SCHEMBL8008459

O=C(CCc1ccc(OCc2ccccc2)cc1)C1CCCCC1

nearest known ligand 0.63

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 9/20 0.63
FFAR4 Q5NUL3 5/20 0.63
HRH3 Q9Y5N1 2/20 0.54
ALDH1A1 P00352 1/20 0.53
CYP2C19 P33261 1/20 0.53
AKR1B1 P15121 1/20 0.51
S1PR5 Q9H228 1/20 0.51
EPHX2 P34913 3/20 0.50
LTA4H P09960 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
TP53 P04637 1/20 0.50
KDM4E B2RXH2 1/20 0.50
KMT2A Q03164 1/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3988138 0.99 FFAR1 (0.65) FFAR1FFAR4HRH3ALDH1A1CYP2C19
SCHEMBL11880887 0.86 ALDH1A1 (0.63) FFAR1ALDH1A1CYP2C19EPHX2SMN1; SMN2
SCHEMBL5880829 0.86 FFAR1 (0.57) FFAR1FFAR4SMN1; SMN2
SCHEMBL5880795 0.84 ALDH1A1 (0.60) FFAR1ALDH1A1CYP2C19EPHX2SMN1; SMN2
SCHEMBL5881049 0.83 FFAR1 (0.62) FFAR1FFAR4HRH3ALDH1A1CYP2C19
SCHEMBL14036245 0.81 ALDH1A1 (0.56) FFAR1ALDH1A1CYP2C19EPHX2SMN1; SMN2
SCHEMBL5880785 0.81 S1PR1 (0.56) FFAR1FFAR4HRH3AKR1B1S1PR5
SCHEMBL3990501 0.79 FFAR4 (0.50) FFAR1FFAR4S1PR5SMN1; SMN2TP53
SCHEMBL26637816 0.79 ALDH1A1 (0.60) FFAR1ALDH1A1CYP2C19EPHX2SMN1; SMN2
SCHEMBL1744939 0.78 FFAR1 (1.00) FFAR1FFAR4AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP claimed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO claimed
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed