Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.70 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16606311 | 0.86 | CYP1A2 (0.63) | CHRNA7CHRM2CYP1A2CYP2D6TDP1 | |
| SCHEMBL8001649 | 0.85 | CYP1A2 (0.65) | CHRNA7CHRNB2CHRNA4CHRM2CYP1A2 | |
| SCHEMBL8363021 | 0.83 | CHRNA7 (1.00) | CHRNA7CHRNB2CHRNA4CHRM2CYP1A2 | |
| SCHEMBL30772178 | 0.83 | CHRNA7 (1.00) | CHRNA7CHRNB2CHRNA4CHRM2CYP1A2 | |
| SCHEMBL22762150 | 0.81 | TDP1 (0.61) | CHRNA7CHRNB2CHRNA4SIGMAR1CHRM2 | |
| SCHEMBL10282657 | 0.80 | TDP1 (0.58) | CHRNA7CHRNB2CHRNA4CHRM2CYP1A2 | |
| SCHEMBL11846860 | 0.80 | CHRNA7 (0.79) | CHRNA7CHRNB2CHRNA4SIGMAR1TDP1 | |
| SCHEMBL10858987 | 0.80 | CYP1A2 (0.55) | CHRNA7CHRM2CYP1A2CYP2D6TDP1 | |
| SCHEMBL11411955 | 0.79 | KCNH2 (0.65) | SIGMAR1 | |
| SCHEMBL8111184 | 0.79 | CHRNB2 (0.47) | CHRNA7CHRNB2CHRNA4SIGMAR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057318-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR ACETHER | SANOFI (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5470855-A | Anticoagulants | SANOFI (FR) | 1995-11-28 | — | — | US | disclosed |