Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 10/20 | 0.55 |
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8017638 | 0.88 | CCR3 (0.58) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL8008853 | 0.85 | CCR3 (0.55) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL8010976 | 0.85 | CCR3 (0.61) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL8010973 | 0.85 | CCR3 (0.61) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL8008852 | 0.85 | CCR3 (0.55) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL8010564 | 0.84 | CCR3 (0.62) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL8010094 | 0.82 | CCR3 (0.54) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL7998205 | 0.82 | CCR3 (0.55) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL7998203 | 0.82 | CCR3 (0.55) | CCR3BACE1CTSBCTSVCTSL | |
| SCHEMBL8014171 | 0.81 | CCR3 (0.66) | CCR3CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000053172-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-14 | — | — | WO | claimed |
| WO-2000027800-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-18 | — | — | WO | claimed |
| WO-2000053172-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-14 | — | — | WO | disclosed |
| WO-2000027800-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-18 | — | — | WO | disclosed |