Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 10/20 | 0.66 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | ELANE | P08246 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.49 |
| ▸ | ITGAL | P20701 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608481 | 1.00 | CCR3 (0.66) | CCR3CA2ELANEMEN1KMT2A | |
| SCHEMBL8017638 | 0.89 | CCR3 (0.58) | CCR3MEN1KMT2ACTSB | |
| SCHEMBL3930225 | 0.88 | CCR3 (0.62) | CCR3ELANE | |
| SCHEMBL3930227 | 0.88 | CCR3 (0.62) | CCR3ELANE | |
| SCHEMBL29447178 | 0.88 | CCR3 (0.62) | CCR3ELANE | |
| SCHEMBL3926453 | 0.87 | CCR3 (0.59) | CCR3CAPN1CTSB | |
| SCHEMBL3926458 | 0.87 | CCR3 (0.59) | CCR3CAPN1CTSB | |
| SCHEMBL449457 | 0.87 | CA2 (0.52) | CCR3CA2ELANEMEN1KMT2A | |
| SCHEMBL9716712 | 0.87 | ELANE (0.64) | ELANEMEN1KMT2ACAPN1CTSB | |
| SCHEMBL10658026 | 0.87 | ELANE (0.64) | ELANEMEN1KMT2ACAPN1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027800-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000004003-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-27 | — | — | WO | disclosed |