Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770114 | 0.78 | GSK3B (0.48) | GSK3BMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL18006899 | 0.78 | GSK3B (0.50) | GSK3BTTRALBMEN1KMT2A | |
| SCHEMBL3125875 | 0.76 | TTR (0.40) | TTRALBMEN1KMT2AGPR35 | |
| SCHEMBL3758179 | 0.76 | CYP3A4 (0.45) | TTRALBMEN1KMT2AGPR35 | |
| SCHEMBL14992457 | 0.76 | CYP3A4 (0.50) | GSK3BMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL19707542 | 0.75 | GSK3B (0.58) | GSK3BTTRALBMEN1KMT2A | |
| SCHEMBL14992135 | 0.75 | GSK3B (0.41) | GSK3BMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL21937817 | 0.75 | POLB (0.44) | TTRALBMEN1KMT2AGPR35 | |
| SCHEMBL2380078 | 0.75 | GSK3B (0.45) | GSK3BMEN1KMT2AALDH1A1PTPN1 | |
| SCHEMBL22408297 | 0.74 | LMNA (0.47) | GSK3BMEN1KMT2AGPR35ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
| US-6057318-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR ACETHER | SANOFI (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5470855-A | Anticoagulants | SANOFI (FR) | 1995-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | GSK3B 2388/4885TTR 4834/4885ALB 4063/4885 |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | GSK3B 2388/4885TTR 4834/4885ALB 4063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.