Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000927 | 0.85 | CYP1A2 (0.53) | CYP1A2CYP2D6CHRNB2CHRNA4PKM | |
| SCHEMBL8009737 | 0.84 | CHRNA7 (0.54) | CYP1A2CYP2D6CHRNB2CHRNA4KMT2A | |
| SCHEMBL104748 | 0.82 | CYP1A2 (0.62) | CYP1A2CYP2D6PKMKMT2AALDH1A1 | |
| SCHEMBL4051277 | 0.79 | CYP1A2 (0.58) | CYP1A2CYP2D6PKMKMT2AALDH1A1 | |
| SCHEMBL14019404 | 0.79 | CYP1A2 (0.58) | CYP1A2CYP2D6PKMKMT2AALDH1A1 | |
| SCHEMBL8009779 | 0.79 | CYP1A2 (0.58) | CYP1A2CYP2D6PKMKMT2AALDH1A1 | |
| SCHEMBL8010600 | 0.79 | CYP3A4 (0.47) | PKMKMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL17198522 | 0.79 | CYP1A2 (0.62) | CYP1A2CYP2D6CHRNB2CHRNA4PKM | |
| SCHEMBL1478205 | 0.78 | SIGMAR1 (0.57) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6645277 | 0.78 | CYP1A2 (0.56) | CYP1A2CYP2D6PKMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057318-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR ACETHER | SANOFI (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5891894-A | 2-AMINO OXAZOLE DERIVATIVES; ANTAGONISTS OF PLATELET ACTIVATING FACTOR USEFUL IN TREATMENT OF ASTHMA, INFLAMMATION, CARDIOVASCULAR DISORDERS, RENAL DISEASES, OR AS CONTRACEPTIVES | SANOFI (FR) | 1999-04-06 | — | — | US | disclosed |
| US-5470855-A | Anticoagulants | SANOFI (FR) | 1995-11-28 | — | — | US | disclosed |