Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 6/20 | 0.69 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12552197 | 0.90 | FAAH (0.85) | FAAHFFAR4FFAR1 | |
| SCHEMBL12552211 | 0.83 | FAAH (0.84) | FAAH | |
| SCHEMBL12552204 | 0.82 | FAAH (1.00) | FAAH | |
| SCHEMBL8001324 | 0.79 | FAAH (0.75) | FAAH | |
| SCHEMBL12552296 | 0.77 | FAAH (0.65) | FAAHFFAR1CYP2C9 | |
| SCHEMBL12552214 | 0.76 | FAAH (0.74) | FAAH | |
| SCHEMBL8002496 | 0.74 | FAAH (0.47) | FAAHFFAR4 | |
| SCHEMBL12552301 | 0.73 | FAAH (0.71) | FAAH | |
| SCHEMBL12646402 | 0.72 | FFAR1 (0.73) | FFAR4FFAR1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4209116 | 0.71 | FFAR1 (0.81) | FFAR4FFAR1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151991-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |