SCHEMBL8010787

SCHEMBL8010787

COc1cc(CCC2(CCc3ccc(O)c(OC)c3)CC(O)=C(Sc3cc(C)c(OCCO)cc3C(C)(C)C)C(=O)O2)ccc1O

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 6/20 0.33
TMEM97 Q5BJF2 6/20 0.33
SIGMAR1 Q99720 6/20 0.33
AURKA O14965 1/20 0.33
KDR P35968 1/20 0.33
AURKB Q96GD4 1/20 0.33
TAAR1 Q96RJ0 2/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31
GAA P10253 1/20 0.31
ALOX5 P09917 1/20 0.31
OR51E2 Q9H255 1/20 0.31
LMNA P02545 1/20 0.31
GLA P06280 1/20 0.31
S1PR1 P21453 1/20 0.31
SHBG P04278 2/20 0.31
PTPN1 P18031 2/20 0.31
NOS2 P35228 1/20 0.31
ADRB2 P07550 3/20 0.31
DRD2 P14416 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8008398 0.90 LDHA (0.30)
SCHEMBL5880861 0.78
SCHEMBL8010546 0.77 LDHA (0.40)
SCHEMBL8011494 0.76 LDHA (0.33)
SCHEMBL5880999 0.76 LDHA (0.32)
SCHEMBL8010519 0.76 LDHA (0.32)
SCHEMBL8014023 0.75 LDHA (0.31)
SCHEMBL8008855 0.74 LDHA (0.30)
SCHEMBL8010360 0.74
SCHEMBL8010407 0.72 LDHA (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP claimed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US claimed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO claimed
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed